Technical Skills
• Scientific data management:
o Analysis and Clinical reporting of Diagnostic, Prognostic and Therapeutic associations of genomic biomarkers in somatic cancers in various aspects like, Gene summaries, Disease ontologies, Drug Databases, Variant databases (ClinVar, COSMIC, TP53 database), Oncology databases (OncoKb, Mycancergenome, PharmGKb, CIVIC), collectively for Variant classifications (CAP/AMP/ASCO classification, FDA Evidence level, etc) using Drug labels, Clinical practice guidelines, Scientific publications and Clinical trials.
o Literature analysis for competitive intelligence using Thomson Reuters, Bioinfobank, clinicaltrials.gov, FDA, PubMed, etc. Compilation of literature data and presentation of analyzed data in project meetings.
• Experimentation:
o In vivo Experiments: Evaluation of pharmacodynamic activities of new chemical compounds (more than 400) in relevant animal models for various drug targets. Consideration of physicochemical properties and pharmacokinetic data for selection of dose regimen.
o Ex vivo analysis: Temporal profiling of biomarkers in plasma and tissue samples by ELISA method, Analysis of biochemical parameters in blood and plasma, Histological analysis.
o Instruments: von Frey Filaments, Dynamic Plantar Aesthesiometer, Incapacitance meter, Plethysmometer, Randall Selitto, Easylyte (Ion Analyzer), Biotek microplate reader, Randox (Chemistry analyzer), Microtome, etc.
• Documentation:
o Creation of SOPs/Work instructions/forms, and documentation related to SOP/WI validations, Implementation of Quality Management System (QMS) for document control
o Data analysis, interpretation, report preparation of generated experimental In Vivo data. Maintaining data in electronic lab notebook, maintaining documents related to laboratory, instrumentation and experimental work.
o Data compilation and analysis of experimental results using softwares such as Graphpad prism, Chem draw, ImageJ, Electronic lab notebook, etc.
• Lab management:
o Interaction with multiple stakeholders: internal departments and external vendors for resource procurement (using SAP and ARIBA softwares), maintenance and calibration of lab instruments, human resources management for carrying out lab activities.
Research Project:
• Dissertation thesis in M. S. (Pharm.) titled, ‘‘Evaluation of efficacy of combination of rutin and prednisolone against adjuvant induced arthritis in rats’’ Under the guidance of Dr. S. Ramakrishna (Principle Scientist) in Department of Pharmacology, IICT, Hyderabad.
• Project in B. Pharm: A survey on: The chances of occurrence of prescription errors during dispensing of LA/SA: Look Alike Sound Alike Drugs. Under the guidance of Prof. Mrudula Bele in N.D.M.V.P.S. College of Pharmacy, Nashik
Genetics
