The goal of this computational research project is to understand how and why caloric restriction (CR) (i.e. limited food intake) extends the lifespan in most species because we want to exploit the same mechanism to eventually extend lifespan in humans. CR is believed to be an ancient rejuvenation mechanism with lots of potential benefits. Due to the lack of funding no dataset can be provided. Therefore, publically available microarray, RNAseq and other datasets must be used to arrive at new conclusions. Good knowledge of the statistical package “R” is very helpful since past analysis have been done with “R” already. Knowledge of the biology of saccharomyces cerevisiae is also a plus since it is used as model organism to test hypotheses derived from this computational investigation. Knowledge of how to use the Galaxy tools is also beneficial. One aim is to discover changes in the combination of gene expression that extend lifespan in yeast. It is required to find the datasets, which could help to answer the research question above. Findings from this analysis should be presented in a publishable format and recommendations for journals to publish the findings should be made. Preliminary results should also be used for NSF research grant application. Research design and rationale should be explained very well in spoken and written format. Literature review is also needed.
I noticed that my text to speech software, on which I am depending to access electronic information, has difficulties reading out the UpWork website to me. Could you therefore please contact me directly visa Skype? My Skype ID is . Could you please send me a Skype invite so we can discuss this and other projects in more details?
If you are interested in this project please contact me for more details.
Thanks again for your time and interest